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Showing 1 to 12 of 53 entries
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Sir Edward Mellanby, 1884-1955: the man, research worker, and statesman.

Annual review of biochemistry

PLATT BS.
PMID: 13363303
Annu Rev Biochem. 1956;25:1-28. doi: 10.1146/annurev.bi.25.070156.000245.

No abstract available.

Repair of DNA Breaks by Break-Induced Replication.

Annual review of biochemistry

Kockler ZW, Osia B, Lee R, Musmaker K, Malkova A.
PMID: 33792375
Annu Rev Biochem. 2021 Jun 20;90:165-191. doi: 10.1146/annurev-biochem-081420-095551. Epub 2021 Apr 01.

Double-strand DNA breaks (DSBs) are the most lethal type of DNA damage, making DSB repair critical for cell survival. However, some DSB repair pathways are mutagenic and promote genome rearrangements, leading to genome destabilization. One such pathway is break-induced...

Tunnels for Protein Export from the Endoplasmic Reticulum.

Annual review of biochemistry

Raote I, Malhotra V.
PMID: 33503381
Annu Rev Biochem. 2021 Jun 20;90:605-630. doi: 10.1146/annurev-biochem-080120-022017. Epub 2021 Jan 27.

The functions of coat protein complex II (COPII) coats in cargo packaging and the creation of vesicles at the endoplasmic reticulum are conserved in eukaryotic protein secretion. Standard COPII vesicles, however, cannot handle the secretion of metazoan-specific cargoes such...

Membrane Exporters of Fluoride Ion.

Annual review of biochemistry

McIlwain BC, Ruprecht MT, Stockbridge RB.
PMID: 33492991
Annu Rev Biochem. 2021 Jun 20;90:559-579. doi: 10.1146/annurev-biochem-071520-112507. Epub 2021 Jan 25.

Microorganisms contend with numerous and unusual chemical threats and have evolved a catalog of resistance mechanisms in response. One particularly ancient, pernicious threat is posed by fluoride ion (F

Mechanisms for Regulating and Organizing Receptor Signaling by Endocytosis.

Annual review of biochemistry

von Zastrow M, Sorkin A.
PMID: 33606955
Annu Rev Biochem. 2021 Jun 20;90:709-737. doi: 10.1146/annurev-biochem-081820-092427. Epub 2021 Feb 19.

Intricate relationships between endocytosis and cellular signaling, first recognized nearly 40 years ago through the study of tyrosine kinase growth factor receptors, are now known to exist for multiple receptor classes and to affect myriad physiological and developmental processes....

Mechanisms of Vertebrate DNA Interstrand Cross-Link Repair.

Annual review of biochemistry

Semlow DR, Walter JC.
PMID: 33882259
Annu Rev Biochem. 2021 Jun 20;90:107-135. doi: 10.1146/annurev-biochem-080320-112510. Epub 2021 Apr 21.

DNA interstrand cross-links (ICLs) covalently connect the two strands of the double helix and are extremely cytotoxic. Defective ICL repair causes the bone marrow failure and cancer predisposition syndrome, Fanconi anemia, and upregulation of repair causes chemotherapy resistance in...

It's Better To Be Lucky Than Smart.

Annual review of biochemistry

Kaback HR.
PMID: 33472005
Annu Rev Biochem. 2021 Jun 20;90:1-29. doi: 10.1146/annurev-biochem-011520-105008. Epub 2021 Jan 20.

Bacterial cytoplasmic membrane vesicles provide a unique experimental system for studying active transport. Vesicles are prepared by lysis of osmotically sensitized cells (i.e., protoplasts or spheroplasts) and comprise osmotically intact, unit-membrane-bound sacs that are approximately 0.5-1.0 μm in diameter...

Designing Biological Circuits: Synthetic Biology Within the Operon Model and Beyond.

Annual review of biochemistry

English MA, Gayet RV, Collins JJ.
PMID: 33784178
Annu Rev Biochem. 2021 Jun 20;90:221-244. doi: 10.1146/annurev-biochem-013118-111914. Epub 2021 Mar 30.

In 1961, Jacob and Monod proposed the operon model of gene regulation. At the model's core was the modular assembly of regulators, operators, and structural genes. To illustrate the composability of these elements, Jacob and Monod linked phenotypic diversity...

The Form and Function of PIEZO2.

Annual review of biochemistry

Szczot M, Nickolls AR, Lam RM, Chesler AT.
PMID: 34153212
Annu Rev Biochem. 2021 Jun 20;90:507-534. doi: 10.1146/annurev-biochem-081720-023244.

Mechanosensation is the ability to detect dynamic mechanical stimuli (e.g., pressure, stretch, and shear stress) and is essential for a wide variety of processes, including our sense of touch on the skin. How touch is detected and transduced at...

Quality Control of Procollagen in Cells.

Annual review of biochemistry

Ito S, Nagata K.
PMID: 33823651
Annu Rev Biochem. 2021 Jun 20;90:631-658. doi: 10.1146/annurev-biochem-013118-111603. Epub 2021 Apr 06.

Collagen is the most abundant protein in mammals. A unique feature of collagen is its triple-helical structure formed by the Gly-Xaa-Yaa repeats. Three single chains of procollagen make a trimer, and the triple-helical structure is then folded in the...

A Natural Product Chemist's Guide to Unlocking Silent Biosynthetic Gene Clusters.

Annual review of biochemistry

Covington BC, Xu F, Seyedsayamdost MR.
PMID: 33848426
Annu Rev Biochem. 2021 Jun 20;90:763-788. doi: 10.1146/annurev-biochem-081420-102432. Epub 2021 Apr 13.

Microbial natural products have provided an important source of therapeutic leads and motivated research and innovation in diverse scientific disciplines. In recent years, it has become evident that bacteria harbor a large, hidden reservoir of potential natural products in...

Metabolic antagonists.

Annual review of biochemistry

SHIVE W, SKINNER CG.
PMID: 13571946
Annu Rev Biochem. 1958;27(3):643-78. doi: 10.1146/annurev.bi.27.070158.003235.

No abstract available.

Showing 1 to 12 of 53 entries